Lower tumour burden and better overall survival in melanoma patients with regional lymph node metastases and negative preoperative ultrasound
Identifieur interne : 004D78 ( Main/Exploration ); précédent : 004D77; suivant : 004D79Lower tumour burden and better overall survival in melanoma patients with regional lymph node metastases and negative preoperative ultrasound
Auteurs : Gasper Pilko [Slovénie] ; Janez Zgajnar [Slovénie] ; Maja Music [Slovénie] ; Marko Hocevar [Slovénie]Source :
- Radiology and Oncology [ 1318-2099 ] ; 2011.
Abstract
The purpose of the study was to evaluate the ability of ultrasound (US) and fine needle aspiration biopsy (FNAB) in reducing the number of melanoma patients requiring a sentinel node biopsy (SNB); to compare the amount of metastatic disease in regional lymph nodes in SNB candidates with clinically uninvolved lymph nodes and of those with US uninvolved lymph nodes; and to compare the overall survival (OS) of both groups.
Between 2000 and 2007, a SNB was successfully performed in 707 patients with melanoma. The preoperative US of the regional lymph node basins was performed in 405 SNB candidates. In 14 of these patients, the US-guided FNAB was positive and they proceeded directly to lymph node dissection. In 391 patients, the preoperative US was either negative (343 patients) or suspicious (48 patients) (US group). In the remaining 316 patients the preoperative US was not performed (non-US group).
The proportion of macrometastatic sentinel lymph nodes (SN), number of metastatic lymph nodes per patient and proportion of nonsentinel lymph node metastases were found to be lower in the US group compared to the non-US group. The smaller tumour burden of the US group was reflected in a significantly better OS of patients with SN metastases.
The preoperative US of regional lymph nodes spares some patients with melanoma from undergoing a SNB. Patients with regional metastases and a negative preoperative US have a significantly lower tumour burden in comparison to those with clinically negative lymph nodes, which is also reflected in a better OS.
Url:
DOI: 10.2478/v10019-011-0028-1
PubMed: 22933981
PubMed Central: 3423764
Affiliations:
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xml:lang="fr">Slovénie</country><wicri:regionArea> Institute of Oncology Ljubljana, Department of Surgical Oncology</wicri:regionArea><wicri:noRegion>Department of Surgical Oncology</wicri:noRegion></affiliation></author><author><name sortKey="Music, Maja" sort="Music, Maja" uniqKey="Music M" first="Maja" last="Music">Maja Music</name><affiliation wicri:level="1"><nlm:aff id="af2-rado-46-01-60"> Institute of Oncology Ljubljana, Department of Radiology, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea> Institute of Oncology Ljubljana, Department of Radiology, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name><affiliation wicri:level="1"><nlm:aff id="af1-rado-46-01-60"> Institute of Oncology Ljubljana, Department of Surgical Oncology, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea> Institute of Oncology Ljubljana, Department of Surgical Oncology</wicri:regionArea><wicri:noRegion>Department of Surgical Oncology</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22933981</idno><idno type="pmc">3423764</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423764</idno><idno type="RBID">PMC:3423764</idno><idno type="doi">10.2478/v10019-011-0028-1</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">004610</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004610</idno><idno type="wicri:Area/Pmc/Curation">004609</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004609</idno><idno type="wicri:Area/Pmc/Checkpoint">002E92</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002E92</idno><idno type="wicri:Area/Ncbi/Merge">005080</idno><idno type="wicri:Area/Ncbi/Curation">005080</idno><idno type="wicri:Area/Ncbi/Checkpoint">005080</idno><idno type="wicri:doubleKey">1318-2099:2011:Pilko G:lower:tumour:burden</idno><idno type="wicri:Area/Main/Merge">004E14</idno><idno type="wicri:Area/Main/Curation">004D78</idno><idno type="wicri:Area/Main/Exploration">004D78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lower tumour burden and better overall survival in melanoma patients with regional lymph node metastases and negative preoperative ultrasound</title><author><name sortKey="Pilko, Gasper" sort="Pilko, Gasper" uniqKey="Pilko G" first="Gasper" last="Pilko">Gasper Pilko</name><affiliation wicri:level="1"><nlm:aff id="af1-rado-46-01-60"> Institute of Oncology Ljubljana, Department of Surgical Oncology, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea> Institute of Oncology Ljubljana, Department of Surgical Oncology</wicri:regionArea><wicri:noRegion>Department of Surgical Oncology</wicri:noRegion></affiliation></author><author><name sortKey="Zgajnar, Janez" sort="Zgajnar, Janez" uniqKey="Zgajnar J" first="Janez" last="Zgajnar">Janez Zgajnar</name><affiliation wicri:level="1"><nlm:aff id="af1-rado-46-01-60"> Institute of Oncology Ljubljana, Department of Surgical Oncology, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea> Institute of Oncology Ljubljana, Department of Surgical Oncology</wicri:regionArea><wicri:noRegion>Department of Surgical Oncology</wicri:noRegion></affiliation></author><author><name sortKey="Music, Maja" sort="Music, Maja" uniqKey="Music M" first="Maja" last="Music">Maja Music</name><affiliation wicri:level="1"><nlm:aff id="af2-rado-46-01-60"> Institute of Oncology Ljubljana, Department of Radiology, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea> Institute of Oncology Ljubljana, Department of Radiology, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name><affiliation wicri:level="1"><nlm:aff id="af1-rado-46-01-60"> Institute of Oncology Ljubljana, Department of Surgical Oncology, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea> Institute of Oncology Ljubljana, Department of Surgical Oncology</wicri:regionArea><wicri:noRegion>Department of Surgical Oncology</wicri:noRegion></affiliation></author></analytic><series><title level="j">Radiology and Oncology</title><idno type="ISSN">1318-2099</idno><idno type="eISSN">1581-3207</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The purpose of the study was to evaluate the ability of ultrasound (US) and fine needle aspiration biopsy (FNAB) in reducing the number of melanoma patients requiring a sentinel node biopsy (SNB); to compare the amount of metastatic disease in regional lymph nodes in SNB candidates with clinically uninvolved lymph nodes and of those with US uninvolved lymph nodes; and to compare the overall survival (OS) of both groups.</p></sec><sec><title>Methods</title><p>Between 2000 and 2007, a SNB was successfully performed in 707 patients with melanoma. The preoperative US of the regional lymph node basins was performed in 405 SNB candidates. In 14 of these patients, the US-guided FNAB was positive and they proceeded directly to lymph node dissection. In 391 patients, the preoperative US was either negative (343 patients) or suspicious (48 patients) (US group). In the remaining 316 patients the preoperative US was not performed (non-US group).</p></sec><sec><title>Results</title><p>The proportion of macrometastatic sentinel lymph nodes (SN), number of metastatic lymph nodes per patient and proportion of nonsentinel lymph node metastases were found to be lower in the US group compared to the non-US group. The smaller tumour burden of the US group was reflected in a significantly better OS of patients with SN metastases.</p></sec><sec><title>Conclusions</title><p>The preoperative US of regional lymph nodes spares some patients with melanoma from undergoing a SNB. 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Schoengen</name></author><author><name sortKey="Schmitz, Pi" uniqKey="Schmitz P">PI Schmitz</name></author><author><name sortKey="Sterry, W" uniqKey="Sterry W">W Sterry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balch, Cm" uniqKey="Balch C">CM Balch</name></author><author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name></author><author><name sortKey="Soong, Sj" uniqKey="Soong S">SJ Soong</name></author><author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name></author><author><name sortKey="Ding, S" uniqKey="Ding S">S Ding</name></author><author><name sortKey="Byrd, Dr" uniqKey="Byrd D">DR Byrd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elias, N" uniqKey="Elias N">N Elias</name></author><author><name sortKey="Tanabe, Kk" uniqKey="Tanabe K">KK Tanabe</name></author><author><name sortKey="Sober, Aj" uniqKey="Sober A">AJ Sober</name></author><author><name sortKey="Gadd, Ma" uniqKey="Gadd M">MA Gadd</name></author><author><name sortKey="Mihm, Mc" uniqKey="Mihm M">MC Mihm</name></author><author><name sortKey="Goodspeed, B" uniqKey="Goodspeed B">B Goodspeed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossi, Cr" uniqKey="Rossi C">CR Rossi</name></author><author><name sortKey="De Salvo, Gl" uniqKey="De Salvo G">GL De Salvo</name></author><author><name sortKey="Bonandini, E" uniqKey="Bonandini E">E Bonandini</name></author><author><name sortKey="Mocellin, S" uniqKey="Mocellin S">S Mocellin</name></author><author><name sortKey="Foletto, M" uniqKey="Foletto M">M Foletto</name></author><author><name sortKey="Pasquali, S" uniqKey="Pasquali S">S Pasquali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name></author><author><name sortKey="Stretch, Jr" uniqKey="Stretch J">JR Stretch</name></author><author><name sortKey="Uren, Rf" uniqKey="Uren R">RF Uren</name></author><author><name sortKey="Ka, Vs" uniqKey="Ka V">VS Ka</name></author><author><name sortKey="Scolyer, Ra" uniqKey="Scolyer R">RA Scolyer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Slovénie</li></country></list><tree><country name="Slovénie"><noRegion><name sortKey="Pilko, Gasper" sort="Pilko, Gasper" uniqKey="Pilko G" first="Gasper" last="Pilko">Gasper Pilko</name></noRegion><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name><name sortKey="Music, Maja" sort="Music, Maja" uniqKey="Music M" first="Maja" last="Music">Maja Music</name><name sortKey="Zgajnar, Janez" sort="Zgajnar, Janez" uniqKey="Zgajnar J" first="Janez" last="Zgajnar">Janez Zgajnar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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